Polynucleotides are becoming a true breakthrough in aesthetic medicine.
Although relatively new, they’ve gained popularity due to their ability to promote bio-regeneration within the skin, which means , encouraging the skin to regenerate and behave better over time. They are particularly effective when combined with other treatments in helping to repair and rejuvenate with minimal risks.
While results take time to appear, polynucleotides can be safely used on the face, scalp, and body, offering a versatile approach to overall skin health.
Whilst I normally do not advocate for trending treatments, this is one that actually lives up to the hype and is the reason why I believe polynucleotide treatments are here to stay!
What exactly are polynucleotides?
You might have heard of this treatment being called the "salmon sperm facial"... In simple terms, polynucleotides are long chains of DNA, derived from highly purified salmon or trout gonadal DNA.
Suspended in water, these DNA fragments are delivered into the skin via injection. Various brands contain different concentrations of polynucleotides (PN-HPT), and at my clinic, I’ve thoroughly researched the best options to ensure the highest quality for my patients. I am excited to offer Plinest, previously known as Plenhyage, which is only available in medical clinics.
Additionally, I provide Newest, a hybrid product containing both polynucleotides and hyaluronic acid, combining the benefits of both ingredients to lift, plump, and rejuvenate the skin.
How do polynucleotides work?
Once injected, these DNA fragments are gradually absorbed into the skin without creating lumps or bumps. As they integrate into your skin, they trigger three key actions.
Firstly, they stimulate fibroblast cells to increase in number and boost activity, which enhances cell renewal. This, in turn, improves collagen production, hydration, and skin radiance, while enhancing elasticity and reducing the appearance of wrinkles.
Secondly, polynucleotides act as powerful antioxidants, scavenging free radicals that typically cause cellular damage.
Lastly, they support wound healing, helping to repair scars, reduce stretch marks, and improve skin texture. As a result, skin discoloration fades, leaving a more even complexion, and you may notice a mild plumping and tightening effect over time.
Results depend on several factors, such as the degree of skin aging, your skin’s ability to regenerate, and lifestyle factors
What can you expect during treatment, and how long before results show?
Polynucleotides are injected just under the surface of your skin, either with tiny needles that leave small bumps (known as blebs), or through a blunt cannula for more even distribution. The blebs usually disappear within a few hours but may linger slightly longer in some cases. With the cannula method, you may experience some swelling for up to a week due to the temporary lifting effect, but this will subside as the product is fully absorbed.
It’s important to note that polynucleotides work at a cellular level, so results take time.
While some improvement may be noticeable after 2-3 weeks, full results typically take around 3 months to become visible.
Patience is key, as these treatments are focused on long-term, natural-looking improvements.
Where can polynucleotides be used?
Polynucleotides can be used on various areas of the skin, from small targeted regions like the under-eye, forehead, or mouth area, to larger areas such as the neck, décolletage, or abdomen.
They are even effective for scalp treatments to promote hair regrowth.
One key advantage of polynucleotides is that they don’t cause water retention, making them ideal for areas like the under-eye where puffiness is a concern.
Before any treatment, I always recommend a face-to-face consultation to determine the best course of action for your specific needs.
Real Results, Real Satisfaction
Don’t just take my word for it. Here are some real-life results:
Are there any risks?
Polynucleotides are incredibly safe.
Salmon DNA is very similar to human DNA, and the highly purified nature of these injections ensures you’re receiving the purest form possible. Unlike dermal fillers, which are suspended in a gel, polynucleotides are suspended in water, meaning there is no risk of blocking blood vessels.
Long-term use is also safe (they have been used in medicine since the 1980s), and in fact, regular treatments may become part of your anti-aging strategy as your skin matures.
How are polynucleotides different from dermal fillers?
Dermal fillers, which consist of hyaluronic acid gels, work primarily by physically adding volume to the skin. The results are often instant and can last anywhere from 6-12 months or longer. However, because hyaluronic acid attracts water, fillers aren’t always suitable for areas prone to puffiness.
Polynucleotides, on the other hand, work by stimulating skin regeneration rather than adding volume. This process takes time, but it offers a more holistic improvement, especially when combined with other treatments.
What’s the difference between Profhilo and polynucleotides?
Profhilo contains one of the highest concentrations of pure hyaluronic acid available, and its hydrating properties give the skin a dewy, plumped look. It also stimulates collagen production, helping with both hydration and skin structure. However, Profhilo is not suitable for areas like the under-eye.
Polynucleotides, meanwhile, do not contain hyaluronic acid (except for the hybrid product Newest) and work by promoting bio-regeneration over a longer period. Both treatments can be combined for a more comprehensive approach, depending on your skin’s needs.
How are skin boosters different from polynucleotides?
Skin boosters focus primarily on hydration and have a mild lifting effect, giving the skin a glow and reducing the appearance of fine lines. However, skin boosters don’t regenerate the skin in the way polynucleotides do.
Polynucleotides go deeper, stimulating collagen production, initiating tissue repair, and improving skin function overall. They don’t add volume, but they provide long-term regenerative effects.
Ready for a refresh?
Polynucleotides are unique in that they work at a cellular level, making them an excellent option for natural, long-lasting skin improvements. Whether used alone or in combination with other treatments, they can provide a natural, refreshed look, making them a fantastic option for anyone looking to invest in their skin's health.
If you’d like to explore how polynucleotides can help you achieve your skin goals, I’d love to chat with you. Book a consultation with me, and let’s create a plan that’s perfect for you!
If you're in Christchurch, Dorset, or nearby areas such as Bournemouth and the New Forest, my clinic is conveniently located for you.
Book a consultation today and let’s discuss how polynucleotides can help transform your skin
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